![]() ![]() Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of the pachymeninges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (mnemonic: SEEPS). An orthostatic headache is the prototypical manifestation but other headache patterns occur as well, and associated symptoms are common. Mechanical factors combine with an underlying connective tissue disorder to cause the CSF leaks. ![]() Women are affected more commonly than men. The incidence has been estimated at 5 per 100 000 per year, with a peak around age 40 years. Reference lists of these articles and ongoing investigations in this area were used as well.Įvidence Synthesis Spontaneous intracranial hypotension is caused by single or multiple spinal CSF leaks. Objective To summarize existing evidence regarding the epidemiology, pathophysiology, diagnosis, and management of spontaneous spinal CSF leaks and intracranial hypotension.Įvidence Acquisition MEDLINE (1966-2005) and OLDMEDLINE (1950-1965) were searched using the terms intracranial hypotension, CSF leak, low pressure headache, and CSF hypovolemia. It is an important cause of new headaches in young and middle-aged individuals, but initial misdiagnosis is common. Shared Decision Making and CommunicationĬontext Spontaneous intracranial hypotension is caused by spontaneous spinal cerebrospinal fluid (CSF) leaks and is known for causing orthostatic headaches.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. ![]()
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